In the quest to rethink education in the United States, we must turn our attention to the science of learning and development. This ever-expanding body of knowledge sheds light on how young people evolve and acquire knowledge. This scientific foundation can serve as our north star as we embark on the transformation of districtwide, schoolwide, and classroom systems, structures, practices, and mindsets. Working together, we possess the potential to overhaul districts and schools in a way that caters to the unique and diverse needs of every student.